Hyperthermia siv ntau yam kev siv cua sov (xov tooj cua zaus, microwave, ultrasound, laser, thiab lwm yam) los ua kom qhov kub ntawm cov nqaij mob qog nce mus txog qhov kub kho tau zoo, ua rau cov hlwb mob qog tuag yam tsis ua rau cov hlwb ib txwm puas tsuaj. Hyperthermia tsis yog tsuas yog ua rau cov hlwb mob qog xwb, tab sis kuj ua rau cov hlwb mob qog loj hlob thiab rov tsim dua tshiab.
Mechanism ntawm hyperthermia
Cov qe ntshav qog noj ntshav, zoo li lwm cov qe ntshav, tau txais ntshav los ntawm cov hlab ntsha kom lawv muaj sia nyob.
Txawm li cas los xij, cov qe ntshav qog tsis tuaj yeem tswj tau qhov ntau ntawm cov ntshav ntws hauv cov hlab ntsha, uas tau raug hloov pauv los ntawm lawv. Hyperthermia, ib txoj kev kho mob, siv qhov tsis muaj zog ntawm cov nqaij mob qog no.
1. Hyperthermia yog kev kho mob qog nqaij hlav thib tsib tom qab phais, radiotherapy, chemotherapy thiab biotherapy.
2. Nws yog ib qho ntawm cov kev kho mob tseem ceeb rau cov qog nqaij hlav (tuaj yeem ua ke nrog ntau yam kev kho mob kom txhim kho kev kho mob ntawm cov qog nqaij hlav).
3. Nws tsis yog tshuaj lom, tsis mob, muaj kev nyab xeeb thiab tsis ua rau mob, tseem hu ua kev kho mob ntsuab.
4. Cov ntaub ntawv kho mob ntau xyoo qhia tau tias kev kho mob zoo, tsis mob, rov zoo sai, tsis muaj kev pheej hmoo, thiab pheej yig rau cov neeg mob thiab tsev neeg (Kev saib xyuas thaum nruab hnub).
5. Txhua yam qog nqaij hlav hauv tib neeg tshwj tsis yog qog nqaij hlav hauv hlwb thiab qhov muag tuaj yeem kho tau (nws tus kheej xwb, lossis ua ke nrog kev phais, kev kho mob radiotherapy, kev kho mob chemotherapy, kev siv stem cell, thiab lwm yam).
Cov qog nqaij hlav cytoskeleton—— ncaj qha ua rau muaj kev puas tsuaj rau cytoskeleton.
Cov qog nqaij hlav - hloov pauv qhov permeability ntawm cov cell membrane, pab txhawb kev nkag mus ntawm cov tshuaj chemotherapeutic, thiab ua tiav cov txiaj ntsig ntawm kev txo qis kev lom thiab nce kev ua haujlwm.
Nruab nrab lub nucleus.
Kev txwv ntawm DNA thiab RNA polymerization ua rau puas tsuaj rau kev loj hlob etiology thiab kev qhia tawm ntawm cov khoom chromosomal proteins khi rau DNA thiab inhibition ntawm protein synthesis.
Cov hlab ntsha ntawm cov qog nqaij hlav
Tiv thaiv kev qhia tawm ntawm cov qog nqaij hlav uas loj hlob tuaj ntawm cov hlab ntsha endothelial thiab nws cov khoom
