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Kev Txhais Lus Txog Kev Kho Mob CAR T-Cell
CAR-T (Chimeric Antigen Receptor T-Cell), uas sawv cev rau chimeric antigen receptor T-cells, yog ib qho txheej txheem uas ib tus neeg cov T cell raug tsim kho sab nraud lub cev kom hloov kho, ua rau lawv muaj peev xwm paub thiab tua cov cell mob qog noj ntshav ua ntej rov muab tso rau hauv tus neeg mob lub cev, yog li ua tiav lub hom phiaj ntawm kev kho cov qog nqaij hlav phem.
Qhov tseeb, CAR-T kev kho mob tsis yog tsuas yog siv rau kev kho mob qog noj ntshav xwb tab sis kuj muaj peev xwm zoo hauv cov teb ntawm cov kab mob autoimmune, cov kab mob ntev, kab mob plawv, thiab cov kab mob ntsig txog hnub nyoog.
Cov qe ntshav T, tseem hu ua T lymphocytes, yog cov khoom tseem ceeb ntawm cov qe ntshav lymphocytes thiab yog lub luag haujlwm tseem ceeb rau kev tiv thaiv kab mob thiab kev tiv thaiv kab mob. Lawv muaj cov haujlwm xws li tua cov qe ntshav ncaj qha, pab thiab txwv tsis pub cov qe ntshav B tsim cov tshuaj tiv thaiv kab mob, teb rau cov antigens thiab mitogens tshwj xeeb, thiab tsim cov cytokines.
Tau kawg, tib neeg lub cev tiv thaiv kab mob tsis yog tsuas yog T cell xwb; nws kuj suav nrog B cell, neutrophils, K cell, NK cell, thiab ntau ntxiv. Lawv ua lub luag haujlwm hauv kev tshem tawm cov khoom pov tseg ntawm lub cev, lees paub thiab tsim cov tshuaj tiv thaiv kab mob, thiab txheeb xyuas thiab tua cov kab mob txawv teb chaws thiab cov cell mob qog noj ntshav.
Vim tias cov T cell twb muaj lub luag haujlwm lees paub thiab tua cov cell mob qog noj ntshav lawm, vim li cas thiaj li yuav tsum ntxiv CAR rau hauv T cell kom tsim cov CAR-T cell los tua cov cell mob qog noj ntshav? Qhov no coj peb mus rau lub tswv yim ntawm kev tiv thaiv kab mob, uas yog ib qho ntawm cov yam ntxwv tseem ceeb tshaj plaws ntawm mob qog noj ntshav.
Kev kho mob CAR-T, lossis CAR-T cell therapy, suav nrog kev cais cov T cell ntawm tus neeg mob, nthuav lawv mus rau sab nraud lub cev, thiab tom qab ntawd muab cov antigen CAR (chimeric antigen receptor) uas tsim los ntawm cov neeg mob rau hauv cov T cell. Tom qab ua tiav lawm, cov haujlwm tiv thaiv kab mob ntawm T lymphocytes tau txhim kho ntau heev ua ntej rov muab tso rau hauv tus neeg mob lub cev, yog li rov qab kho cov T cell kom paub thiab tua cov cell mob qog noj ntshav. Qhov no yog lub ntsiab lus ntawm kev kho mob CAR-T cell.
Impact Bio txoj kev kho mob CAR-T IMPT-514 tau txais kev pom zoo los ntawm FDA.
Thaum Lub Yim Hli 21, 2024, Impact Bio tshaj tawm tias FDA tau pom zoo nws daim ntawv thov IND rau IMPT-514 kev kho mob uas nws tsim. IMPT-514 yog bispecific CD19/CD20 CAR-T kev kho mob siv los kho cov kab mob lupus erythematosus (SLE). Hauv cov ntaub ntawv sim tshuaj, IMPT-514 tau pom tias muaj txiaj ntsig zoo hauv kev tsim cov neeg mob uas muaj kev tiv thaiv kab mob hnyav los ntawm ntau yam kab mob autoimmune, thiab nws tau ua pov thawj tias muaj peev xwm tshem tawm B-cell autologous nrog cov cytokine profile me me. Axicabtagene ciloleucel CAR-T kev kho mob rau B-cell lymphoma loj tseem qhia txog kev teb rov qab tom qab tsib xyoos. Thaum Lub Yim Hli 2, 2024, American Society of Clinical Oncology (ASCO) tau tshaj tawm cov ntaub ntawv qhia txog cov nqi ciaj sia ntev tom qab CAR-T cell kev kho mob. Cov txiaj ntsig tau qhia tias ntawm cov neeg mob uas tau txais kev kho mob CAR-T, tus nqi ciaj sia nyob 5-xyoo uas tsis muaj kev nce qib yog 29%, tus nqi ciaj sia nyob 5-xyoo tag nrho (OS) yog 40%, thiab tus nqi ciaj sia nyob 5-xyoo lymphoma tshwj xeeb yog 53%, nrog rau kev rov qab mob lig tsawg tsawg. Axicabtagene ciloleucel yog ib qho kev kho mob CD19 chimeric antigen receptor CAR-T cell uas tau pom zoo rau kev kho mob ntawm cov kab mob B-cell lymphoma uas rov qab mob lossis tsis kho tau. Xaus Lus: Hauv qhov chaw kho mob tus qauv, cov txiaj ntsig kev kho mob ntawm axicabtagene ciloleucel CAR-T yog sib xws nrog cov txiaj ntsig tau tshaj tawm hauv kev sim tshuaj, nrog rau cov lus teb ruaj khov, ruaj khov pom ntawm lub cim 5-xyoo.
Kev kho mob CAR-T thawj zaug ua tiav hauv ntiaj teb rau cov kab mob autoimmune.Thaum Lub Kaum Hli 4, 2024, lub vev xaib Nature tau tshaj tawm ib daim ntawv qhia txog kev tshawb fawb los ntawm pab pawg neeg Suav. Cov kws tshawb fawb tau siv CRISPR-Cas9 gene-editing technology los tsim cov hlwb CAR-T uas tau txais kev noj qab haus huv los ntawm cov neeg pub dawb uas tsom mus rau CD19, tsim ib tiam tshiab ntawm kev kho mob CAR-T thoob ntiaj teb uas tau pab peb tus neeg mob uas muaj cov kab mob autoimmune hnyav kom ua tiav kev zam txim mus sij hawm ntev.
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"Lung nodule cryoablation" teeb meem kev kho mob uas ua rau neeg mob tuag tes tuag taw
Kev tswj hwm cov qog hauv lub ntsws niaj hnub suav nrog kev kuaj nqaij thiab kev phais mob ntsws.
Cov teeb meem xws li pneumothorax thiab hemothorax yooj yim tshwm sim thaum lub sijhawm biopsy.
Muaj kev pheej hmoo ntawm kev poob cov qe ntshav dawb thiab kev nthuav dav mus rau lwm qhov chaw. Nws nyuaj rau kev kuaj mob vim tias muaj cov ntaub so ntswg me me uas siv los kuaj mob.
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Mob qog nqaij hlav ntsws
Mob qog nqaij hlav ntsws (tseem hu ua mob qog nqaij hlav ntsws) yog mob qog nqaij hlav ntsws phem uas tshwm sim los ntawm cov ntaub so ntswg epithelial ntawm ntau qhov sib txawv. Raws li qhov tsos, nws muab faib ua hauv nruab nrab, sab nraud thiab loj (sib xyaw).
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Mob Cancer ntawm Txoj Hnyuv
Thaum pib mob qog hauv txoj hnyuv, tsis muaj tsos mob tsis xis nyob thiab tsis mob, tab sis koj tuaj yeem pom cov qe ntshav liab hauv cov quav los ntawm kev kuaj cov quav thiab kuaj cov ntshav zais, qhia tias muaj ntshav hauv txoj hnyuv. Kev kuaj gastroscopy tuaj yeem pom cov kab mob tshiab tseem ceeb hauv txoj hnyuv thaum pib mob.
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Mob Cancer Pancreatic
Mob qog nqaij hlav pancreatic yog ib qho mob qog nqaij hlav uas ua rau tuag taus tshaj plaws uas cuam tshuam rau lub pancreas, ib lub cev nyob tom qab lub plab. Nws tshwm sim thaum cov hlwb tsis zoo hauv lub pancreas pib loj hlob tawm ntawm kev tswj hwm, tsim ib lub qog. Cov theem thaum ntxov ntawm mob qog nqaij hlav pancreas feem ntau tsis ua rau muaj tsos mob. Thaum lub qog loj hlob, nws tuaj yeem ua rau muaj tsos mob xws li mob plab, mob nraub qaum, poob phaus, tsis xav noj mov, thiab mob daj ntseg. Cov tsos mob no tuaj yeem tshwm sim los ntawm lwm yam mob thiab, yog li nws yog ib qho tseem ceeb uas yuav tsum mus ntsib kws kho mob yog tias koj muaj ib qho ntawm lawv.
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Mob qog nqaij hlav prostate
Mob qog nqaij hlav prostate yog ib hom mob qog nqaij hlav phem uas feem ntau pom thaum cov hlwb qog nqaij hlav prostate loj hlob thiab kis mus rau hauv lub cev txiv neej, thiab nws qhov tshwm sim nce ntxiv nrog hnub nyoog. Txawm hais tias kev kuaj mob thaum ntxov thiab kev kho mob tseem ceeb heev, qee qhov kev kho mob tseem tuaj yeem pab qeeb qhov kev loj hlob ntawm tus kab mob thiab txhim kho tus nqi ciaj sia ntawm cov neeg mob. Mob qog nqaij hlav prostate tuaj yeem tshwm sim rau txhua lub hnub nyoog, tab sis feem ntau nws yog qhov feem ntau tshwm sim rau cov txiv neej hnub nyoog tshaj 60 xyoo. Feem ntau cov neeg mob qog nqaij hlav prostate yog txiv neej, tab sis kuj tseem yuav muaj poj niam thiab cov txiv neej sib deev.
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Mob Cancer ntawm zes qe menyuam
Lub zes qe menyuam yog ib qho tseem ceeb ntawm cov poj niam lub cev tsim menyuam, thiab tseem yog lub cev tseem ceeb ntawm cov poj niam. Nws lub luag haujlwm yog tsim qe thiab tsim thiab tso cov tshuaj hormones. Nrog rau tus nqi siab ntawm cov poj niam. Nws ua rau cov poj niam lub neej thiab kev noj qab haus huv muaj kev phom sij heev.
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Mob qog nqaij hlav raum
Kab mob qog nqaij hlav hauv lub raum yog ib hom qog nqaij hlav phem uas pib los ntawm cov hlab ntsha hauv lub raum. Lo lus kawm yog kab mob qog nqaij hlav hauv lub raum, tseem hu ua kab mob qog nqaij hlav hauv lub raum, hu ua kab mob qog nqaij hlav hauv lub raum. Nws suav nrog ntau hom kab mob qog nqaij hlav hauv lub raum uas pib los ntawm ntau qhov ntawm cov hlab ntsha hauv lub raum, tab sis tsis suav nrog cov qog nqaij hlav uas pib los ntawm cov hlab ntsha hauv lub raum thiab cov qog nqaij hlav hauv lub raum. Thaum ntxov li xyoo 1883, Grawitz, tus kws kho mob German, tau pom tias... -
Mob Cancer Pob Txha
Mob qog nqaij hlav pob txha yog dab tsi? Qhov no yog ib qho tshwj xeeb uas muaj cov qauv, lub cev, thiab pob txha tib neeg. Txawm li cas los xij, txawm tias lub cev no zoo li khov kho kuj yuav raug tso tseg thiab ua qhov chaw nkaum rau cov qog nqaij hlav phem. Cov qog nqaij hlav phem tuaj yeem tsim tau ntawm nws tus kheej thiab kuj tuaj yeem tsim los ntawm kev rov tsim dua ntawm cov qog nqaij hlav zoo. Feem ntau, yog tias peb tham txog mob qog nqaij hlav pob txha, peb txhais tau tias yog mob qog nqaij hlav metastatic, thaum cov qog nqaij hlav loj hlob hauv lwm cov kabmob (lub ntsws, lub mis, prostate) thiab kis mus rau theem kawg, suav nrog pob txha ... -
Mob qog nqaij hlav siab
Mob qog noj ntshav hauv siab yog dab tsi? Ua ntej, cia peb kawm txog ib yam kab mob hu ua mob qog noj ntshav. Nyob rau hauv cov xwm txheej ib txwm muaj, cov hlwb loj hlob, faib, thiab hloov cov hlwb qub kom tuag. Qhov no yog ib qho txheej txheem zoo uas muaj lub tshuab tswj hwm meej. Qee zaum cov txheej txheem no raug rhuav tshem thiab pib tsim cov hlwb uas lub cev tsis xav tau. Qhov tshwm sim yog tias cov qog nqaij hlav tuaj yeem yog cov qog nqaij hlav tsis muaj mob lossis cov qog nqaij hlav phem. Cov qog nqaij hlav tsis muaj mob tsis yog mob qog noj ntshav. Lawv yuav tsis kis mus rau lwm qhov ntawm lub cev, thiab lawv yuav tsis loj hlob dua tom qab phais. Txawm hais tias... -
Carcinoma ntawm qhov quav
Carcinomaofrectum yog hu ua mob qog noj ntshav colorectal, yog ib hom qog mob phem uas feem ntau pom hauv txoj hnyuv plab thiab txoj hlab pas, qhov tshwm sim yog qhov thib ob tom qab mob qog noj ntshav plab thiab txoj hlab pas, yog qhov feem ntau pom ntawm mob qog noj ntshav colorectal (kwv yees li 60%). Feem ntau ntawm cov neeg mob muaj hnub nyoog tshaj 40 xyoo, thiab kwv yees li 15% muaj hnub nyoog qis dua 30 xyoo. Txiv neej muaj ntau dua, qhov piv ntawm txiv neej rau poj niam yog 2-3: 1 raws li kev soj ntsuam hauv tsev kho mob, pom tias ib feem ntawm mob qog noj ntshav colorectal tshwm sim los ntawm cov polyps rectal lossis schistosomiasis; mob ntev ntawm txoj hnyuv, qee qhov tuaj yeem ua rau mob qog noj ntshav; kev noj zaub mov uas muaj roj ntau thiab muaj protein ntau ua rau muaj kev tso tawm ntawm cholic acid ntau ntxiv, qhov tom kawg raug rhuav tshem mus rau hauv cov hydrocarbons polycyclic unsaturated los ntawm cov kab mob hauv plab, uas kuj tuaj yeem ua rau mob qog noj ntshav.
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Mob qog nqaij hlav ntawm lub qhov ncauj tsev menyuam
Kab mob qog nqaij hlav ntawm lub tsev menyuam, tseem hu ua kab mob qog nqaij hlav ntawm lub tsev menyuam, yog kab mob qog nqaij hlav uas tshwm sim ntau tshaj plaws hauv txoj hlab ntaws ntawm cov poj niam. HPV yog qhov tseem ceeb tshaj plaws uas ua rau muaj kab mob no. Kab mob qog nqaij hlav ntawm lub tsev menyuam tuaj yeem tiv thaiv tau los ntawm kev kuaj mob thiab txhaj tshuaj tiv thaiv kab mob tsis tu ncua. Kab mob qog nqaij hlav ntawm lub tsev menyuam thaum ntxov kho tau zoo heev thiab qhov kev kwv yees tau zoo heev.
Lub koom haum kho mob koom tes ntawm Beijing Cancer Hospital