Tsis ntev los no, Antengene txoj kev tshawb fawb theem I/II CLINCH ntawm ATG-022 (CLDN18.2 antibody-drug conjugate), ib tug neeg mob laus uas muaj mob qog noj ntshav hauv plab uas tau nce qib ntawm ntau txoj kev kho mob chemotherapy, immunotherapy thiab targeted therapy txawm tias muaj metastases ntau heev los ua tiav qhov kev teb tiav (CR) tom qab ATG-022 monotherapy. Tus neeg mob tsis muaj qog nqaij hlav tau lees paub los ntawm PET/CT thaum lub Tsib Hlis 2025.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
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WeChat ID: 17801183037
Email：myimmnet@163.com
ATG-022 yog CLDN18.2 ADC uas Antengene tau tshawb pom thiab tsim tawm hauv tsev. Ntawm lub rooj sib tham ASCO GI 2025 thaum ntxov xyoo no, Antengene tau nthuav tawm cov ntaub ntawv kho mob tshiab rau ATG-022. Hauv cov neeg mob uas muaj kev qhia tawm CLDN18.2 nruab nrab mus rau siab (IHC 2+ ≥ 20%), tus nqi teb lub hom phiaj (ORR) yog 42.9%, thiab tus nqi tswj kab mob (DCR) yog 95.2%. Ntawm cov neeg mob uas muaj kev qhia tawm CLDN18.2 qis (IHC 2+ < 20%), ORR yog 30.0%, thiab DCR yog 50.0%. Cov ntaub ntawv no qhia tau tias ATG-022 muab kev ua haujlwm zoo thiab kev nyab xeeb zoo thoob plaws ntau yam kev qhia tawm CLDN18.2, suav nrog kev qhia tawm siab, qis, thiab txawm tias qis heev. Nws cov kev ua haujlwm tiv thaiv kab mob qog nqaij hlav dav dav qhia tau tias ATG-022 yuav muab cov txiaj ntsig kho mob rau cov neeg mob dav dua piv rau lwm cov kev kho mob CLDN18.2. Tam sim no, kev tshawb fawb txog kev nthuav dav ntawm ATG-022 theem II tseem tab tom ua nyob rau hauv thaj av loj ntawm Tuam Tshoj thiab Australia.
Qhov kev ua tiav ntawm CR hauv tus neeg mob qog noj ntshav hauv plab no yog qhov txhawb siab heev, qhia txog lub peev xwm kho mob ntawm ATG-022 ua kev kho mob ADC tshiab. Qhov tseem ceeb, qhov no tsis yog tib qho CR uas tau pom hauv kev tshawb fawb tam sim no. Txog niaj hnub no, muaj peb tus neeg mob CR tau pom, suav nrog cov neeg mob los ntawm ob lub tebchaws Suav teb thiab Australia. Antengene tos ntsoov yuav nthuav tawm cov ntaub ntawv tshiab los ntawm kev tshawb fawb ATG-022 ntawm ESMO Congress uas yuav los txog rau lub Kaum Hli 2025.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Lub sijhawm tshaj tawm: Lub Yim Hli-21-2025