Thaum Lub Yim Hli 22, 2025, Datopotamab deruxtecan (Dato-DXd; Datroway) tau txais kev pom zoo hauv Suav teb rau kev kho mob rau cov neeg mob laus uas muaj mob qog noj ntshav hauv lub mis uas tsis tuaj yeem phais lossis kis mus rau lwm qhov, HER2-negative (immunohistochemistry [IHC] 0, IHC 1+, lossis IHC 2+/in situ hybridization [ISH] negative) uas tau txais kev kho mob endocrine thiab tsawg kawg 1 kab chemotherapy hauv qhov chaw siab heev.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Qhov kev pom zoo no yog raws li cov txiaj ntsig zoo ntawm kev tshawb fawb thoob ntiaj teb Theem III TROPION-Breast01. Kev tshawb fawb thoob ntiaj teb, theem 3, qhib-daim ntawv lo, randomized TROPION-Breast01 tau soj ntsuam cov trophoblast cell surface antigen 2-directed antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) piv rau kev xaiv ntawm tus kws tshawb fawb ntawm chemotherapy (ICC) hauv hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2–) mob qog noj ntshav hauv lub mis.
Cov neeg mob tau raug xaiv los ntawm Dato-DXd (n = 365) lossis ICC (n = 367). Dato-DXd txo qhov kev pheej hmoo ntawm kev nce qib lossis kev tuag piv rau ICC (PFS los ntawm BICR kev phom sij piv [HR], 0.63 [95% CI, 0.52 txog 0.76]; P < .0001). Cov txiaj ntsig PFS sib xws tau pom thoob plaws cov pab pawg me. Txawm hais tias cov ntaub ntawv OS tsis tau loj hlob, qhov sib txawv nyiam Dato-DXd tau pom (HR, 0.84 [95% CI, 0.62 txog 1.14]). Tus nqi ntawm qib ≥3 kev kho mob-cuam tshuam cov xwm txheej tsis zoo (TRAEs) nrog Dato-DXd qis dua ICC (20.8% v 44.7%). Cov TRAEs feem ntau (txhua qib; qib ≥3) yog xeev siab (51.1%; 1.4%) thiab stomatitis (50%; 6.4%) nrog Dato-DXd thiab neutropenia (pawg lus, 42.5%; 30.8%) nrog ICC.
Cov neeg mob uas tau txais Dato-DXd muaj kev txhim kho tseem ceeb thiab muaj txiaj ntsig zoo hauv PFS thiab muaj kev nyab xeeb zoo thiab tswj tau, piv rau ICC.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Lub sijhawm tshaj tawm: Lub Yim Hli-26-2025