Tsis ntev los no, ib tug neeg mob uas muaj mob qog nqaij hlav pancreatic uas tau ua tsis tiav ntau txoj kev kho mob yav dhau los tau ua rau mob qog nqaij hlav me me tom qab tau txais kev kho mob KD-496 CAR-T cell, nrog rau kev zam txim tau pom tseeb tias tseem nyob hauv 180 hnub tom qab kev kho mob.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email:myimmnet@163.com
Tus neeg mob, ib tug poj niam hnub nyoog 73 xyoo, tau kuaj pom tias muaj qog nqaij hlav hauv lub taub hau pancreatic nrog rau cov kua tsib tsawg. Nws tau phais duodenectomy, thaum lub sijhawm ntawd pom muaj qog nqaij hlav khov kho li 3 cm loj ntawm qhov txheej txheem pancreatic uncinate. Kev kuaj mob tau lees paub tias muaj qog nqaij hlav adenocarcinoma sib txawv me ntsis. Tom qab phais, nws tau txais albumin-bound paclitaxel (nab-paclitaxel) ua ke nrog S-1 chemotherapy, ua raws li M108 + nab-paclitaxel + gemcitabine thiab LM108 ua ke nrog toripalimab. Nws muaj keeb kwm ntawm schizophrenia thiab ntshav qab zib, ob qho tib si tswj tau zoo nrog tshuaj.
Thaum Lub Ob Hlis Ntuj xyoo 2025, tus neeg mob tau txais cov qe ntshav KD-496 CAR-T. Thaum thawj zaug soj ntsuam qog nqaij hlav plaub lub lis piam tom qab, txawm tias nws muaj hnub nyoog laus thiab muaj qog nqaij hlav ntau (qhov mob pib ntawm 58 mm), qhov mob tau me dua 34.5% ntawm qhov pib. Txog hnub 60, qhov mob tau me dua 37.9%, thiab txog hnub 90 thiab 180, qhov mob txuas ntxiv me dua 44.8%, tswj tau qhov kev teb ib nrab (PR) yam tsis muaj kev lom rau lub plab zom mov lossis lub paj hlwb.
Ib tug neeg mob qog nqaij hlav uas muaj hnub nyoog 70 xyoo tau phais mob thaum Lub Ob Hlis Ntuj xyoo 2023, nrog rau kev mob tom qab phais mob qhia txog ib qho qog nqaij hlav uas muaj qhov mob me me mus rau qhov tsis zoo uas twb tau kis mus rau cov qog ntshav hauv lub plab, lub plab hnyuv, thiab ob lub ntsws, nrog rau cov kua dej hauv lub plab thiab cov kua dej hauv lub plab (mob hnyav heev, kis mus rau ntau qhov). Yim lub lis piam tom qab phais mob, nws tau txais kev kho mob SOX chemotherapy (oxaliplatin + S-1), tab sis nws tus mob tau nce zuj zus. Kev sim tom qab ntawd nrog PX (paclitaxel) + PD-1 (immunotherapy) rau plaub lub voj voog, ua raws li capecitabine + nivolumab, kuj tsis tau ua rau kev nce zuj zus. Thaum kawg, nivolumab + fruquintinib (tshuaj tiv thaiv kab mob angiogenic) tau muab, tab sis muaj txiaj ntsig tsawg.
Nyob rau hnub 28 ntawm kev kho mob CAR-T, lub qog tau me dua 47.3% piv rau kev kho mob ua ntej, ua tiav qhov kev teb tob ib nrab (PR). Txog hnub 60, lub qog txuas ntxiv me dua 41.9%, tswj hwm qhov PR uas tau lees paub, qhia txog kev kho mob uas ruaj khov thiab ua tau zoo.
Ib tug neeg mob qog nqaij hlav hnub nyoog 55 xyoo tau phais mob qog nqaij hlav hauv lub Kaum Ib Hlis 2023, nrog rau kev mob tom qab phais mob qhia tias muaj qog nqaij hlav adenocarcinoma tsis zoo nrog rau qog nqaij hlav signet-ring cell carcinoma (mob heev). Nws tau sim ntau yam kev kho mob chemotherapy + immunotherapy, suav nrog oxaliplatin + capecitabine + sintilimab, oxaliplatin + leucovorin + sintilimab, nab-paclitaxel + sintilimab + fruquintinib, thiab irinotecan monotherapy. Txawm li cas los xij, thaum Lub Ob Hlis 2025, nws tus mob tau mob sai sai, ua rau cov kev kho mob ib txwm tsis zoo.
Tom qab ntawd nws tau txais kev kho mob CAR-T cell, thiab thaum txog hnub 28, lub qog tau me dua 31.8% piv rau kev kho mob ua ntej, ua tiav ib feem ntawm kev teb (PR), nrog rau kev tswj kab mob tau ua tiav.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email:myimmnet@163.com
Lub sijhawm tshaj tawm: Lub Xya Hli-31-2025