Thaum Lub Peb Hlis Ntuj hnub tim 31, 2026, Lub Chaw Saib Xyuas Kev Tshuaj Xyuas Tshuaj ntawm Tuam Tshoj Lub Chaw Tswj Xyuas Khoom Siv Kho Mob Hauv Tebchaws tau tshaj tawm xov xwm zoo siab: GFH375, tsim los ntawm GenFleet Therapeutics, tau raug suav hais tias yog "Kev Kho Mob Tshiab" rau kev kho mob rau cov neeg mob uas muaj mob qog noj ntshav pancreatic uas kis mus rau lwm qhov chaw uas muaj KRAS G12D mutation uas tau txais tsawg kawg ib zaug kev kho mob thoob plaws lub cev. Qhov no yog ib kauj ruam tseem ceeb hauv kev kho mob kom raug rau mob qog noj ntshav pancreatic.
Yog tias koj lossis ib tus neeg koj hlub tab tom muaj teeb meem nrog mob qog noj ntshav pancreatic KRAS G12D-mutant, tsis txhob poob siab. Lub Tsev Kho Mob Beijing South Region Oncology Hospital International Department (400-880-3716) tab tom ua raws li qhov kev txhim kho tshiab no thiab muab kev sab laj thiab kev sib koom tes kho mob rau cov neeg mob thoob ntiaj teb.
**Txog GFH375/VS-7375**
GFH375 yog ib qho tshuaj uas siv tau hauv qhov ncauj, muaj zog, thiab xaiv tau cov tshuaj me me KRAS G12D (ON/OFF) inhibitor uas tsim los rau kev sib pauv GTP/GDP, ua rau txoj kev ua haujlwm ntawm txoj kev mus rau sab qis thiab tiv thaiv tau cov hlwb qog nqaij hlav kom loj hlob zoo. Cov kev tshawb fawb ua ntej kuaj mob tau qhia txog kev txwv tsis pub noj tshuaj hauv cov qauv uas muaj KRAS G12D mutations; GFH375 kuj qhia tau tias muaj kev pheej hmoo tsawg hauv kev xaiv kinase thiab kev ntsuam xyuas kev nyab xeeb.
GenFleet tau koom tes nrog Verastem Oncology (Nasdaq: VSTM) los tshawb pom thiab txhim kho peb txoj kev pab cuam oncology tshiab uas tsom mus rau RAS/MAPK txoj kev mob qog noj ntshav. Kev koom tes no muab kev xaiv tshwj xeeb rau Verastem kom tau txais daim ntawv tso cai rau txhua yam ntawm peb yam tshuaj tom qab ua tiav cov hom phiaj tseem ceeb hauv kev sim theem I. Thaum Lub Kaum Ob Hlis Ntuj xyoo 2023, Verastem tau xaiv GFH375/VS-7375, uas yog ib yam tshuaj uas noj tau los ntawm KRAS G12D (ON/OFF), ua nws txoj haujlwm tseem ceeb los ntawm kev koom tes, thiab daim ntawv tso cai rau GFH375 uas tau siv rau lub Ib Hlis Ntuj xyoo 2025 yog thawj zaug los ntawm kev koom tes no. Cov ntawv tso cai no muab Verastem txoj cai tsim kho thiab kev lag luam sab nraum Suav teb, thaum GenFleet tseem khaws cov cai hauv Suav teb.
**Cov ntaub ntawv sim tshuaj theem I/II zoo heev uas tau nthuav tawm ntawm 2025 ESMO Congress:**
- 91.5% ntawm cov neeg mob tau pom tias cov qhov txhab ntawm cov neeg mob tau txo qis
- Tus nqi teb rau lub hom phiaj (ORR) tau txog 40.7%
- Tus nqi tswj kab mob (DCR) siab txog li 96.7%
- Lub sijhawm muaj sia nyob nruab nrab uas tsis muaj kev nce qib (mPFS) yog 5.52 lub hlis
- Tus nqi ciaj sia nyob 4 lub hlis yam tsis muaj kev nce qib yog 78.2%
Cov ntaub ntawv no, tau los ntawm 59 tus neeg mob uas muaj KRAS G12D-mutant pancreatic ductal adenocarcinoma (PDAC) uas tau txais kev kho mob yav dhau los, qhia tau zoo txog kev ua haujlwm tiv thaiv qog ntawm GFH375 hauv kev mob qog nqaij hlav pancreatic uas tsis kho tau.
Vim li cas ho xaiv Beijing South Region Oncology Hospital International Department? **
Ua ib tug thawj coj hauv kev pabcuam kho mob thoob ntiaj teb, Beijing South Region Oncology Hospital International Department tau cog lus tias yuav muab kev pabcuam rau cov neeg mob thoob ntiaj teb nrog:
- Kev pab tswv yim thiab teem caij kho mob ntau hom lus
- Nkag mus rau cov kws tshaj lij oncology hauv Suav teb thiab thoob ntiaj teb
- Ib txoj kev ntsuab rau kev kho mob hla ciam teb
Peb nkag siab tias rau cov neeg mob uas muaj mob qog noj ntshav siab heev, txhua hnub ntxiv uas tos yuav ua rau muaj kev pheej hmoo ntau dua. Yog li ntawd, peb tau tsim ntau txoj kev sib cuag thoob ntiaj teb uas yooj yim kom ntseeg tau tias koj tau txais kev pab txhawb nqa raws sijhawm.
**Tiv tauj peb hnub no thiab pib koj txoj kev taug kev ntawm kev cia siab**
��� Xov tooj kub: 400-880-3716
��� WeChat: 17801183037
��� Email:
- 100085_010@163.com
- myimmnet@163.com
Txawm koj nyob lub teb chaws twg los yog cheeb tsam twg los xij, lossis koj twb tau sim ntau txoj kev kho mob lawm los xij, Beijing South Region Oncology Hospital International Department yeej npaj txhij los nrog koj sib ntaus sib tua mob qog noj ntshav. Kev vam meej tshiab ntawm GFH375 tej zaum yuav yog lub teeb uas koj tau tos ntsoov.
Call 400-880-3716, add us on WeChat at 17801183037, or email us at 100085_010@163.com or myimmnet@163.com.
Ua ke, cia peb siv zog rau ntau txoj hauv kev rau lub neej.
> Lus Cim: GFH375 tseem tsis tau txais kev pom zoo ua lag luam hauv Suav teb. Nws lub npe hu ua Breakthrough Therapy yuav ua rau kev nkag mus rau hauv tsev kho mob sai dua. Lub Tsev Kho Mob Thoob Ntiaj Teb Beijing South Region Oncology yuav saib xyuas kev nce qib hauv kev nkag mus rau cov tshuaj thiab muab cov ntaub ntawv hais txog kev kho mob tshiab thiab kev sib koom tes rau cov neeg mob uas tsim nyog. Thov ua raws li koj tus kws kho mob cov lus qhia txog cov phiaj xwm kho mob tshwj xeeb.
Lub sijhawm tshaj tawm: Plaub Hlis-10-2026