Thaum Lub Yim Hli 29, Boehringer Ingelheim's HERNEXEOS® (zongertinib ntsiav tshuaj) tau txais kev pom zoo los ntawm Tuam Tshoj Lub Chaw Saib Xyuas Khoom Siv Kho Mob Hauv Tebchaws (NMPA) rau kev kho mob rau cov neeg laus uas muaj mob qog nqaij hlav tsis loj hlob sai (NSCLC) uas tsis tuaj yeem phais tau, mob qog nqaij hlav hauv zos lossis mob qog nqaij hlav uas kis mus rau lwm qhov (metastatic) uas cov qog nqaij hlav muaj HER2 (ERBB2) hloov pauv thiab cov uas tau txais tsawg kawg ib kab ntawm kev kho mob yav dhau los.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Kev pom zoo raws li cov ntaub ntawv los ntawm qhov kev sim theem Ib Beamion-LUNG 1 (NCT04886804): Kev sim theem I uas qhib rau pej xeem siv, nrog kev lees paub thiab nthuav dav ntawm cov tshuaj zongertinib ua kev kho mob ib leeg rau cov neeg uas muaj cov qog nqaij hlav uas tsis tuaj yeem phais lossis kis mus rau lwm qhov nrog HER2 kev hloov pauv. Kev tshawb fawb muaj 2 ntu. Ntu thawj zaug yog qhib rau cov neeg laus uas muaj ntau hom qog nqaij hlav siab heev nrog HER2 kev hloov pauv uas suav nrog kev hloov pauv, kev nthuav dav, kev qhia ntau dhau thiab kev sib xyaw rau cov neeg uas kev kho mob yav dhau los tsis ua tiav. Ntu thib ob yog qhib rau cov neeg uas muaj qog nqaij hlav HER2-mutant non-small cell lung cancer.
Hauv pawg neeg thib 1, tag nrho muaj 75 tus neeg mob tau txais zongertinib ntawm koob tshuaj 120 mg. Thaum lub sijhawm txiav cov ntaub ntawv (Kaum Ib Hlis 29, 2024), 71% ntawm cov neeg mob no (95% kev ntseeg siab [CI], 60 txog 80; P<0.001 tawm tsam qhov ntsuas ≤30%) tau lees paub tias muaj kev teb zoo; lub sijhawm nruab nrab ntawm kev teb yog 14.1 lub hlis (95% CI, 6.9 tsis tuaj yeem ntsuas tau), thiab lub sijhawm nyob nruab nrab tsis muaj kev nce qib yog 12.4 lub hlis (95% CI, 8.2 tsis tuaj yeem ntsuas tau). Cov teeb meem tsis zoo ntawm tshuaj theem 3 lossis siab dua tau tshwm sim hauv 13 tus neeg mob (17%). Hauv pawg neeg thib 5 (31 tus neeg mob), 48% ntawm cov neeg mob (95% CI, 32 txog 65) tau lees paub tias muaj kev teb zoo. Cov teeb meem tsis zoo ntawm tshuaj theem 3 lossis siab dua tau tshwm sim hauv 1 tus neeg mob (3%). Hauv pawg neeg thib 3 (20 tus neeg mob), 30% ntawm cov neeg mob (95% CI, 15 txog 52) tau pom tias muaj kev teb zoo. Cov teeb meem tsis zoo ntawm cov tshuaj theem 3 lossis siab dua tau tshwm sim hauv 5 tus neeg mob (25%). Hauv peb pawg neeg, tsis muaj cov neeg mob uas muaj kab mob ntsws interstitial uas cuam tshuam nrog cov tshuaj tau tshwm sim.
"Nws yog ib qho kev txhawb siab uas pom NMPA txuas ntxiv lees paub txog lub peev xwm ntawm zongertinib. Kev Tsim Kho Tshiab rau kev siv thawj kab ntawm zongertinib hauv Suav teb qhia txog qhov xav tau ceev ceev hauv cov neeg mob no. Nws yog ib kauj ruam tseem ceeb tom ntej los ua kom txoj kev kho mob no muaj rau ntau tus neeg mob uas xav tau, "Shashank Deshpande, Tus Thawj Coj ntawm Pawg Thawj Coj ntawm Boehringer Ingelheim hais.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Lub sijhawm tshaj tawm: Cuaj hlis-02-2025