Tsis ntev los no, Ascentage Pharma tshaj tawm tias nws cov tshuaj tshiab Bcl-2 selective inhibitor lisaftoclax (APG-2575) tau txais kev pom zoo los ntawm Tuam Tshoj Lub Chaw Saib Xyuas Khoom Siv Kho Mob Hauv Tebchaws (NMPA) rau kev kho mob rau cov neeg laus uas muaj mob leukemia lymphocytic/lymphocytic lymphoma me me (CLL/SLL) uas tau txais tsawg kawg ib qho kev kho mob thoob plaws lub cev suav nrog Bruton's tyrosine kinase (BTK) inhibitors, uas ua rau lisaftoclax yog thawj Bcl-2 inhibitor tau txais kev pom zoo thiab kev tso cai ua lag luam rau kev kho mob rau cov neeg mob uas muaj CLL/SLL hauv Suav teb, thiab thib ob Bcl-2 inhibitor tau pom zoo thoob ntiaj teb.
Lisaftoclax yog ib yam tshuaj tshiab uas Ascentage Pharma tsim los kho cov neeg mob uas muaj mob qog noj ntshav los ntawm kev xaiv thaiv cov protein antiapoptotic Bcl-2 thiab ua rau cov txheej txheem apoptosis rov qab zoo li qub hauv cov hlwb qog noj ntshav. Hauv kev sim tshuaj, lisaftoclax tau pom tias muaj peev xwm kho tau ntau yam mob qog noj ntshav thiab cov qog nqaij hlav, tshwj xeeb tshaj yog hauv CLL/SLL, ob qho tib si ua ib qho kev kho mob ib leeg thiab ua ke.
Qhov kev pom zoo no yog raws li cov txiaj ntsig los ntawm kev tshawb fawb tseem ceeb ntawm Theem II (APG2575CC201) uas tau tsim los ntsuam xyuas qhov ua tau zoo thiab kev nyab xeeb ntawm lisaftoclax monotherapy rau cov neeg mob uas rov qab los yog tsis kho CLL / SLL, nrog rau qhov kev teb tag nrho (ORR) ua qhov kawg tseem ceeb. Lisaftoclax tau ua pov thawj tias muaj txiaj ntsig zoo thiab ORR uas ua tau raws li qhov kawg tau teev tseg rau cov neeg mob uas tau kho nrog BTK inhibitors thiab / lossis immunochemotherapy yav dhau los. Ntxiv mus, lisaftoclax tau qhia txog kev nyab xeeb zoo uas tsis muaj mob qog nqaij hlav (TLS) tshwm sim thaum lub sijhawm tshawb fawb, qhov tshwm sim tsawg ntawm cov tshuaj lom hematologic uas tswj tau, thiab qhov tshwm sim tsawg ntawm cov tshuaj lom tsis yog hematologic uas feem ntau yog qib 1-2.
CLL/SLL yog ib qho mob qog ntshav uas tshwm sim los ntawm cov qog B-cell loj hlob. Nws feem ntau cuam tshuam rau cov pej xeem laus uas muaj ntau dua 100,000 tus neeg mob tshiab tau tshaj tawm thoob ntiaj teb txhua xyoo1. Hauv Suav teb, qhov twg tus nqi ntawm CLL/SLL qis dua li ntawm cov tebchaws sab hnub poob, tus kab mob no tshwm sim ntawm tus nqi nce sai, nrog rau hnub nyoog hluas dua thiab muaj kev ua phem ntau dua2. Raws li kev xaiv thawj zaug tam sim no rau kev kho mob thawj kab ntawm CLL/SLL, BTK inhibitors tau txhim kho cov txiaj ntsig kev kho mob rau cov neeg mob. Txawm li cas los xij, BTK inhibitors tseem ntsib ntau yam teeb meem xws li muaj peev xwm txwv tsis pub ua kom muaj kev teb tob, muaj kev pheej hmoo siab ntawm kev rov qab los hauv kev kho mob nruab nrab thiab ntev, kev lom thiab kev tsis kam lees nrog kev kho mob ntev; yog li, qhov xav tau kev kho mob zoo dua thiab muaj txiaj ntsig zoo dua rau cov neeg mob uas muaj CLL/SLL.
Kev qhia txog Bcl-2 inhibitors tau hloov pauv txoj kev kho mob CLL/SLL. Tus apoptosis suppressor factor Bcl-2, feem ntau overexpressed hauv ntau yam mob hematologic malignancies, tshwj xeeb tshaj yog CLL/SLL, yog ib qho tseem ceeb uas cov qog nqaij hlav zam kev apoptosis. Txawm li cas los xij, kev tshawb pom ntawm Bcl-2 inhibitor ua lub hom phiaj kho mob yog qhov nyuaj heev vim tias nws txoj kev ua haujlwm yog raws li kev sib cuam tshuam ntawm cov protein-protein (PPI). Lub interface khi ntawm Bcl-2 yog qhov loj heev, ua rau nws nyuaj rau cov tshuaj me me inhibitors kom muaj kev thaiv. Tsis tas li ntawd, Bcl-2 protein nyob ntawm mitochondria, nrog ob-membrane qauv, yog ib qho ntawm cov khoom siv cellular nyuaj tshaj plaws vim nws xav tau cov tshuaj kom nkag mus rau hauv lub cell membrane ua ntej lawv tuaj yeem ua haujlwm ntxiv rau ntawm mitochondrial membrane. Ua ntej qhov no, tsis muaj Bcl-2 inhibitor tau pom zoo rau kev kho mob CLL/SLL hauv Suav teb. Qhov kev pom zoo rau lisaftoclax no ua kom tiav qhov sib txawv ntawm kev kho mob hauv CLL/SLL, coj kev cia siab tshiab rau ntau tus neeg mob hauv lub tebchaws.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
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Lub sijhawm tshaj tawm: Lub Xya Hli-15-2025