Thaum Lub Xya Hli 31, AstraZeneca thiab Merck & Co. tau tshaj tawm ua ke tias lawv cov tshuaj PARP inhibitor Lynparza, ua ke nrog Abiraterone thiab prednisolone, tau txais kev pom zoo hauv Suav teb rau kev kho mob rau cov neeg laus uas muaj mob qog nqaij hlav prostate uas tiv taus metastatic castration (mCRPC) uas muaj cov noob caj noob ces lossis somatic BRCA mutations (gBRCAm lossis sBRCAm).
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email:myimmnet@163.com
Lynparza (olaparib) yog thawj zaug hauv chav kawm PARP inhibitor thiab thawj zaug kev kho mob tsom mus rau thaiv DNA puas tsuaj teb (DDR) hauv cov hlwb/qog uas muaj qhov tsis txaus hauv HRR, xws li kev hloov pauv hauv BRCA1 thiab/lossis BRCA2. Kev txwv ntawm PARP nrog Lynparza ua rau muaj kev ntes ntawm PARP khi rau DNA ib txoj hlua tawg, nres ntawm replication forks, lawv tawg thiab tiam ntawm DNA ob txoj hlua tawg thiab mob qog noj ntshav tuag.
Qhov kev pom zoo no yog raws li cov txiaj ntsig ntawm kev tshuaj xyuas pawg me los ntawm cov neeg thoob ntiaj teb thiab Suav teb ntawm PROpel Theem III kev sim. PROpel yog kev sim tshuaj theem III uas tsis muaj kev kuaj mob, ob chav dig muag, ntau lub chaw soj ntsuam kev ua haujlwm, kev nyab xeeb, thiab kev kam rau siab ntawm Lynparza ua ke nrog Abiraterone thiab prednisolone piv rau placebo ntxiv rau Abiraterone thiab prednisolone rau cov neeg mob txiv neej uas muaj mCRPC uas tsis tau txais kev kho mob chemotherapy lossis kev kho mob hormonal tshiab (NHA) ntawm theem mCRPC.
Cov ntaub ntawv los ntawm pawg neeg mob thoob ntiaj teb uas muaj kev hloov pauv BRCA qhia tau hais tias Lynparza ua ke nrog Abiraterone tau ua pov thawj tias muaj kev txhim kho tseem ceeb hauv kev muaj sia nyob tsis muaj kev nce qib hauv kev siv tshuaj radiographic (rPFS) piv rau Abiraterone monotherapy. Kev tshuaj xyuas pawg neeg mob uas muaj kev hloov pauv BRCA hauv pawg neeg mob thoob ntiaj teb tau qhia tias Lynparza ua ke nrog Abiraterone txo qhov kev pheej hmoo ntawm kev mob hnyav lossis kev tuag los ntawm 76% thiab qhov kev pheej hmoo ntawm kev tuag los ntawm 70%. Qhov nruab nrab rPFS thiab qhov nruab nrab ntawm kev muaj sia nyob (OS) hauv pawg Lynparza ntxiv rau Abiraterone tseem tsis tau mus txog, thaum qhov nruab nrab rPFS thiab qhov nruab nrab OS hauv pawg Abiraterone monotherapy yog 8 lub hlis thiab 23 lub hlis, raws li.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Lub sijhawm tshaj tawm: Lub Yim Hli-07-2025