Thaum Lub Tsib Hlis 1, 2025, Hansoh Pharmaceutical tshaj tawm tias Pawg Neeg tus kheej tsim B7-H4-targeted antibody-drug conjugate (ADC) HS-20089 rau kev txhaj tshuaj tau txais kev pom zoo kom suav nrog ua Breakthrough-Therapy-Designated Drug los ntawm National Medical Products Administration (NMPA) ntawm Tuam Tshoj, nrog rau cov lus qhia rau platinum-resistant recurrent epithelial ovarian cancer, fallopian tube cancer lossis primary peritoneal cancer.
Qhov kev xaiv no tau txais kev txhawb nqa los ntawm cov txiaj ntsig los ntawm Kev Tshawb Fawb Theem I HS-20089-101 thiab Kev Tshawb Fawb Theem II HS-20089-201. Kev tshawb fawb HS-20089-101 yog kev sim tshuaj theem I uas muaj ntau lub chaw, qhib rau kev soj ntsuam los ntsuas kev nyab xeeb, kev kam rau siab, kev siv tshuaj, thiab kev ua tau zoo ntawm HS-20089 rau kev txhaj tshuaj rau cov neeg mob uas muaj mob qog nqaij hlav loj heev. Kev tshawb fawb HS-20089-201 yog kev sim tshuaj theem II uas muaj ntau lub chaw, qhib rau kev soj ntsuam los ntsuas kev ua tau zoo, kev nyab xeeb, cov ntaub ntawv siv tshuaj, thiab kev tiv thaiv kab mob ntawm HS-20089 rau cov neeg mob uas muaj mob qog nqaij hlav zes qe menyuam rov tshwm sim lossis kis mus rau lwm qhov thiab mob qog nqaij hlav endometrial.
HS-20089 yog B7-H4-targeted ADC nrog rau topoisomerase inhibitor (TOPOi) payload uas tau tsim los rau kev kho mob qog nqaij hlav zes qe menyuam thiab lwm yam qog nqaij hlav poj niam hauv ntau qhov kev sim tshuaj hauv Suav teb, nrog rau theem kev tshawb fawb siab tshaj plaws yog Theem III kev sim tshuaj. B7-H4 yog ib qho glycoprotein transmembrane immune checkpoint uas tau qhia tawm ntau hauv ntau yam qog nqaij hlav, suav nrog qog nqaij hlav endometrial thiab qog nqaij hlav zes qe menyuam, tab sis muaj kev qhia tawm tsawg hauv cov ntaub so ntswg ib txwm muaj.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
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Lub sijhawm tshaj tawm: Tsib Hlis-09-2025