PLB1004, tsim los ntawm Beijing Avistone Biotechnology Co., Ltd., yog ib qho kev nyab xeeb, xaiv tau zoo heev, thiab ua haujlwm tau zoo irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) siv rau kev kho mob qog nqaij hlav tsis yog me me (NSCLC).
Thaum Lub Plaub Hlis 9, 2025, Lub Chaw Saib Xyuas Kev Tshuaj Xyuas Tshuaj Hauv Tebchaws (CDE) tau qhia tias PLB1004 ntawm Beijing Avistone Biotechnology tau npaj siab yuav suav nrog hauv kev kho mob tshiab rau cov neeg mob uas muaj mob qog nqaij hlav hauv zos lossis METastatic non-small cell lung cancer (NSCLC) uas muaj EGFR mutation, met amplification thiab / lossis overexpression tom qab kev kho mob EGFR-TKI tsis ua tiav.
Cov txiaj ntsig kho mob thawj zaug ntawm PLB1004 ua ke nrog Vebreltinib hauv kev kho mob rau cov neeg mob qog nqaij hlav ntsws uas tsis yog cov qe me me uas muaj kev hloov pauv EGFR, MET amplification lossis MET overexpression tom qab EGFR-TKI tau tshaj tawm ntawm 2024 Lub Rooj Sib Tham Thoob Ntiaj Teb txog Qog Nqaij Hlav.
Plaub caug plaub tus neeg mob tau txais Vebreltinib 100mg ntxiv rau PLB1004 160mg (n = 15), Vebreltinib 150mg ntxiv rau PLB1004 160mg (n = 13), Vebreltinib 200mg ntxiv rau PLB1004 80mg (n = 3), lossis Vebreltinib 150mg ntxiv rau PLB1004 80mg (n = 13) thiab tau suav nrog hauv kev tshuaj xyuas kev nyab xeeb tag nrho. Ntawm 44 tus neeg mob uas tau soj ntsuam, 36.4% ntawm cov neeg mob tau muaj kev sib kis hauv lub hlwb thiab 86.4% ntawm cov neeg mob tau txais EGFR-TKI tiam thib peb, raws li. Cov lus teb tau tshwm sim thoob plaws txhua qib Vebreltinib thiab PLB1004 koob tshuaj uas tau sim, nrog rau cov lus teb ib nrab (PRs) pom hauv 19/32 (59.4%) cov neeg mob uas tau ntsuas cov lus teb. Ntawm cov neeg mob uas muaj kev sib kis hauv lub hlwb, ORR yog 75.0% (9/12). Tus ORR yog 58.6% (17/29) rau cov neeg mob uas tau txais EGFR-TKI tiam thib peb ua ntej. Cov TRAEs feem ntau yog pob khaus thiab paronychia. Tsis muaj cov neeg mob uas tsis tau tso tseg kev kho mob vim yog TRAEs.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
Email：myimmnet@163.com
Lub sijhawm tshaj tawm: Plaub Hlis-10-2025