Thaum Lub Tsib Hlis 12, 2025, CARsgen tshaj tawm cov ntaub ntawv kho mob thawj zaug rau CT0596, ib qho allogeneic BCMA-targeted CAR-T tsim los ntawm kev siv lub platform THANK-u Plus ™. CT0596 tam sim no raug soj ntsuam hauv kev tshawb fawb kho mob thaum ntxov rau relapsed/refractory multiple myeloma (R/R MM) lossis relapsed/refractory plasma cell leukemia (R/R PCL) los ntsuas nws txoj kev nyab xeeb, thiab kev ua haujlwm thawj zaug.
Txij li thaum Lub Tsib Hlis 6, 2025, 8 tus neeg mob uas muaj R/R MM uas tau txais tsawg kawg peb kab kev kho mob yav dhau los tau sau npe thiab txhaj tshuaj CT0596 tom qab lymphodepletion nrog FC regimen (fludarabine 22.5-30 mg/m² thiab cyclophosphamide 350-500 mg/m²). Cov ntsiab lus tseem ceeb los ntawm txog plaub lub hlis ntawm kev saib xyuas suav nrog:
Tsis muaj kev tshaj tawm txog kev siv tshuaj ntau dhau (dose-limiting toxicities - DLTs), ≥Grade 3 cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), lossis graft-versus-host disease (GVHD). Cov khoom no tau ua pov thawj tias muaj kev nyab xeeb zoo, tsis muaj tus neeg mob tso tseg kev kho mob vim muaj teeb meem tshwm sim.
1) Ntawm 5 tus neeg mob uas ua tiav qhov kev ntsuam xyuas thawj zaug ntawm Lub Limtiam 4, 3 tus neeg mob (60%) tau ua tiav qhov kev teb tiav / kev teb tiav (sCR / CR), thiab 4 tus neeg mob (80%) tau ua tiav qhov tsawg kawg nkaus ntawm cov kab mob seem (MRD) -negativity hauv pob txha. 2) Cov ntaub ntawv thaum ntxov ntawm 2 tus neeg mob ntawm Hnub 14 qhia tau tias muaj kev txo qis ntawm cov qhov txhab uas ntsuas tau los ntawm ≥92% thiab ≥65%, raws li. 3) 1 tus neeg mob tseem tsis tau mus txog lub sijhawm ntsuam xyuas qhov ua tau zoo raws li cov txheej txheem.
Txhua tus neeg mob sCR/CR tseem nyob hauv cov lus teb txuas ntxiv, suav nrog tus neeg mob thawj zaug uas ua tiav plaub lub hlis saib xyuas.
Raws li cov ntaub ntawv kev nyab xeeb thiab kev ua tau zoo ua ntej, CT0596 tau ua pov thawj tias muaj kev kam rau siab thiab txhawb nqa cov cim qhia txog kev ua tau zoo hauv cov neeg mob R/R MM thoob plaws txhua qib koob tshuaj uas tau teev tseg ua ntej, nrog rau kev nthuav dav CAR-T. Cov kev tshawb pom no tsim nyog tshawb nrhiav ntxiv tsis yog hauv R/R MM xwb, tab sis kuj tseem muaj lwm yam kab mob plasma cell thiab cov kab mob autoimmune uas cuam tshuam los ntawm autoreactive plasma cells.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
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Lub sijhawm tshaj tawm: Tsib Hlis-15-2025