Thaum Lub Yim Hli 13, 2025, Pacific Time, lub vev xaib official ntawm 2025 Lub Rooj Sib Tham Thoob Ntiaj Teb txog Kab Mob Cancer Ntsws (WCLC) tau tshaj tawm cov ntawv tshawb fawb xaiv rau lub rooj sib tham xyoo no, Ntawm cov ntsiab lus tseem ceeb yog cov ntawv tshiab rau thawj zaug hauv tib neeg theem 1 kev sim tshuaj ntawm HLX43, Henlius 'PD-L1 ADC.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
HLX43 yog ib hom tshuaj ADC uas muaj ntau yam kev siv los tiv thaiv kab mob qog nqaij hlav uas tsom mus rau PD-L1, uas muaj ob txoj hauv kev sib xyaw ua ke kev thaiv qhov chaw kuaj mob thiab kev lom tshuaj uas cuam tshuam nrog cov khoom thauj. Cov ntaub ntawv ua ntej kev kho mob tau qhia tias, HLX43 muaj cov txiaj ntsig zoo los tiv thaiv kab mob qog nqaij hlav thiab muaj kev kam rau siab zoo hauv cov kab mob qog nqaij hlav tsis yog qog me me (NSCLC), qog nqaij hlav caj dab (CC), qog nqaij hlav esophageal squamous cell carcinoma (ESCC), thiab lwm hom qog nqaij hlav uas tiv taus PD-1/L1 mAb.
Raws li cov ntawv sau tshiab, HLX43 tseem qhia tau tias muaj kev teb sai sai rau cov neeg mob uas muaj cov qog nqaij hlav loj heev, tshwj xeeb tshaj yog rau cov neeg mob NSCLC uas tau kho ua ntej thiab tsis tau txais kev kho mob checkpoint inhibitor. HLX43 ua tau zoo dua hauv cov pab pawg me, nrog rau qhov teb sai sai (ORR) ntawm 47.4% hauv EGFR wild-type non-squamous NSCLC, thaum tswj hwm qhov kev nyab xeeb zoo. Qhov tseem ceeb, HLX43 ua tau zoo txawm tias PD-L1 qhia txog nws cov biomarker-independent antitumor peev xwm.
Zoo rau Kev Kho Mob Tom Qab ntawm CPI-Resistant NSCLC: Txij li thaum Lub Ob Hlis 28, 2025, tag nrho muaj 85 tus neeg mob tau txais HLX43. Hauv Theem Ia (kev nce koob tshuaj), 21 tus neeg mob uas muaj cov qog nqaij hlav loj heev tau raug sau npe, thaum nyob rau Theem Ib (kev nce koob tshuaj), 64 tus neeg mob NSCLC tau raug xaiv los ntawm peb pawg (2, 2.5, thiab 3 mg/kg). Qhov tseem ceeb, 88.2% (75/85) ntawm cov neeg mob tsis tau ua tiav kev kho mob ua ntej checkpoint inhibitor (CPI).
Kev Ua Haujlwm Zoo Hauv NSCLC Nrog Cov Txiaj Ntsig Tseem Ceeb Hauv Cov Pab Pawg Tshwj Xeeb: Ntawm 76 tus neeg mob NSCLC (69 tus neeg ntsuas tau qhov ua tau zoo), ORR yog 31.9% (22/69), nrog rau tus nqi tswj kab mob (DCR) ntawm 87.0% (60/69). Kev tshuaj xyuas pawg me tau qhia txog kev ua haujlwm zoo ntawm HLX43 hauv cov pej xeem tshwj xeeb: cov neeg mob 2 mg / kg thiab 2.5 mg / kg hauv Theem Ib tau txais ORR ntawm 38.1% (8/21) thiab 33.3% (7/21), feem; cov neeg mob CPI-refractory NSCLC (n = 61) tau qhia txog ORR ntawm 32.8% (20/61); cov neeg mob EGFR qus-hom tsis-squamous NSCLC (n = 19) muaj ORR ntawm 47.4% (9/19).
Kev Nyab Xeeb Zoo, Kev Ua Haujlwm Zoo nrog Kev Lom Zem Tsawg: Hauv Theem Ia, muaj ib qho xwm txheej DLT uas cuam tshuam nrog febrile neutropenia tau pom hauv pawg 4 mg / kg. Cov xwm txheej tsis zoo ntsig txog kev kho mob (TRAEs) tau tshaj tawm hauv 95.2% ntawm cov neeg mob, feem ntau yog Qib 1-2. Qib ≥3 TRAEs tau tshwm sim hauv 5 tus neeg mob (23.8%), tag nrho los ntawm 3 thiab 4 mg / kg cohorts, feem ntau txo qis neutrophil suav (19%), txo qis cov qe ntshav dawb suav (19.0%) thiab ntshav tsis txaus (14.3%). Cov xwm txheej tsis zoo ntsig txog kev tiv thaiv kab mob (irAEs) tau tshaj tawm hauv kev tshawb fawb no qhia tias HLX43 muaj peev xwm ua rau muaj kev cuam tshuam kev tiv thaiv kab mob. Qhov tseem ceeb, cov neeg mob uas tau tshaj tawm irAEs tau ua pov thawj tias muaj kev teb sai dua (ORR).
Zoo rau cov xwm txheej biomarker sib txawv: PD-L1-zoo NSCLC cov neeg mob (n = 50) tau pom ORR ntawm 32.0% (16/50) thaum PD-L1-tsis zoo / tsis paub cov neeg mob (n = 19) tau ua tiav ORR ntawm 31.6% (6/19), tsis muaj qhov sib txawv tseem ceeb pom.
Tam sim no, tseem muaj ntau qhov kev sim tshuaj kho mob qog noj ntshav tshiab hauv Suav teb nrhiav cov neeg mob. Kev sab laj txog cov tshuaj tshiab thiab cov thev naus laus zis, koj tuaj yeem tiv tauj Beijing South Region Oncology Hospital International Department.
Xov Tooj: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Lub sijhawm tshaj tawm: Lub Yim Hli-15-2025