Thaum Lub Peb Hlis 10, 2026, cov tshuaj B7-H3-targeting antibody-drug conjugate (ADC) YL201 tshiab rau kev txhaj tshuaj, tsim los ntawm MediLink Therapeutics, tau txais Breakthrough Therapy Designation los ntawm Center for Drug Evaluation of China's National Medical Products Administration. Cov lus qhia tshwj xeeb yog ua ke nrog Serplulimab rau kev kho mob thawj kab ntawm theem siab me me mob qog noj ntshav ntsws (ES-SCLC).
YL201 yog ib qho ADC tshiab uas tsom mus rau B7H3. Cov protein B7H3 no muaj ntau dhau rau cov hlwb phem thiab cov hlwb pib mob qog noj ntshav ntawm ntau hom qog noj ntshav tab sis nws muaj kev txwv tsis pub muaj kev qhia tawm hauv cov nqaij ib txwm muaj, qhia txog nws lub peev xwm ua lub hom phiaj tshuaj ADC. YL201 tau tsim los ntawm kev siv MediLink's Tumor Microenvironment Activable LINker-payload (TMALIN®) thev naus laus zis sib txuas nrog cov tshuaj tiv thaiv B7H3 tshwj xeeb heev. Tam sim no, YL201 tab tom raug tshawb nrhiav hauv ntau yam qog noj ntshav khov kho thiab tau nkag mus rau hauv kev sim theem tseem ceeb hauv Small Cell Lung Cancer thiab Nasopharyngeal Carcinoma hauv Suav teb.
### Cov Ntaub Ntawv Kho Mob Muaj Cai: Kev Ua Haujlwm Zoo thiab Kev Nyab Xeeb Zoo
Thaum Lub Peb Hlis Ntuj xyoo 2025, phau ntawv xov xwm thoob ntiaj teb *Nature Medicine* tau tshaj tawm cov ntaub ntawv los ntawm Theem 1/1b kev sim tshuaj ntawm YL201 rau cov neeg mob uas muaj cov qog nqaij hlav loj heev. Txoj kev tshawb fawb no, suav nrog 312 tus neeg mob, tau qhia txog:
- **Kev Ua Haujlwm Zoo Tag Nrho:** Ntawm 287 tus neeg mob uas tau soj ntsuam, qhov feem pua ntawm kev teb (ORR) yog qhov zoo kawg nkaus 40.8%, suav nrog 2 tus neeg mob ua tiav kev teb tiav (CR) thiab 115 tus neeg ua tiav kev teb ib nrab (PR). Tus nqi tswj kab mob (DCR) tau txog 83.6%.
- **Kab Mob Cancer Ntsws Me Me Theem Ntev (ES-SCLC):** Hauv cov neeg mob uas tau kho nrog tshuaj chemotherapy uas siv platinum ua ntej, ORR yog 63.9%, DCR yog 91.7%, thiab lub neej nyob nruab nrab uas tsis muaj kev nce qib (mPFS) yog 6.3 lub hlis.
- **Kab Mob Cancer Nasopharyngeal (NPC):** Ntawm 70 tus neeg mob, ORR yog 48.6%, DCR yog 92.9%, nrog rau 2 tus neeg mob tau teb tiav. Lub sijhawm nruab nrab ntawm kev teb (mDOR) ntev li 8.4 lub hlis.
Cov ntaub ntawv no lees paub tag nrho cov haujlwm tiv thaiv qog thiab cov ntaub ntawv kev nyab xeeb ntawm YL201 hla ntau hom qog nqaij hlav siab heev, tso lub hauv paus ruaj khov rau kev tshawb fawb tom ntej thiab kev siv dav dua.
### Tsev Kho Mob Beijing South Region Oncology Department Thoob Ntiaj Teb: Koj Lub Choj Mus Rau Kev Kho Mob Thoob Ntiaj Teb
Lub Tsev Kho Mob Thoob Ntiaj Teb ntawm Beijing South Region Oncology yeej mob siab rau kev qhia txog cov thev naus laus zis thiab tshuaj kho mob qog noj ntshav thoob ntiaj teb. Peb ua raws li kev tshawb fawb tshiab thiab sib koom tes nrog cov tsev kawm ntawv qib siab hauv tebchaws thiab thoob ntiaj teb, siv zog los muab kev kho mob rau cov neeg mob thoob ntiaj teb raws sijhawm, suav nrog YL201.
Peb pab neeg International Patient Services tuaj yeem muab rau koj:
- **Kev Soj Ntsuam Kev Kho Mob Raws Li Tus Kheej:** Ib pab neeg ua haujlwm ntau yam kev kawm (MDT) yuav soj ntsuam koj cov ntaub ntawv kho mob kom meej meej kom paub seb kev kho mob ADC puas haum rau koj tus mob.
- **Kev Nkag Mus Rau Kev Kho Mob Yooj Yim Dua:** Kev pab txog kev tau txais daim ntawv hla tebchaws rau Suav teb, teem sijhawm rau kev sab laj nrog kws tshaj lij, npaj cov kev pab txhais lus, thiab kev sib koom tes nkag mus rau hauv tsev kho mob kom tsis txhob muaj kev txhawj xeeb.
### Tiv tauj peb tam sim no kom paub ntau ntxiv
Yog tias koj lossis ib tus neeg koj hlub tab tom ntsib teeb meem ntsig txog mob qog nqaij hlav me me hauv lub ntsws, mob qog nqaij hlav nasopharyngeal, lossis lwm yam qog nqaij hlav loj heev, thiab xav paub ntxiv txog kev kho mob ADC tshiab lossis ntsuam xyuas cov kev kho mob, thov hu rau Beijing South Region Oncology Hospital International Department tam sim ntawd. Peb cov kws tshwj xeeb International Patient Services yuav teb koj cov lus nug hauv 24 teev.
**Cov Ntaub Ntawv Tiv Tauj:**
- **Xov Tooj:** 400-880-3716
- **WeChat:** 17801183037
- **Email:**
100085_010@163.com
myimmnet@163.com
Peb nkag siab tias txoj kev kho mob qog noj ntshav nyuaj heev, tab sis txhua qhov kev tawg ua rau muaj kev cia siab tshiab. Beijing South Region Oncology Hospital International Department xav sawv nrog koj, siv cov cuab yeej kho mob thiab kev saib xyuas sov so, muaj kev khuv leej, los sib koom kov yeej qog noj ntshav thiab puag ncig lub neej tshiab.
Lub sijhawm tshaj tawm: Lub Peb Hlis-24-2026